Insulin resistance, diabetes, and the insulin-regulated trafficking of GLUT-4.
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چکیده
منابع مشابه
Insulin resistance, diabetes, and the insulin-regulated trafficking of GLUT-4
D AB~T~S affects ~,5% of people in the United States of America and the incidence is much higher in sporadic populations such as Pima Indians in North America and Australian Aborigines. There are two major forms of diabetes, referred to as insulin-dependent diabetes (IDD) ~ and non-insulin-dependent diabetes (NIDD). The etiology of these diseases is quite different despite similarities in their...
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A major consequence of insulin binding its receptor on fat and muscle cells is translocation of the facilitative glucose transporter GLUT4 from an intracellular store to the cell surface where it serves to clear glucose from the bloodstream. Sorting of GLUT4 into its insulin-sensitive store requires the GGA [Golgi-localized, γ-ear-containing, ADP ribosylation factor (ARF)-binding] adaptor prote...
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Objective: Resistance exercise is recommended as effective treatments for people with type 2 diabetes. However, the impact of this mode of exercise on blood glucose, insulin and insulin resistance in Iranian's type 2 diabetic patients is unclear. We conducted a systematic review of the literature for the effect of resistance exercise training on these clinical markers in Iranian's type 2 diabet...
متن کاملTargeting of the insulin-regulatable glucose transporter (GLUT-4).
668 A family of facilitative glucose transporters (GLUTS 1-7) has recently been identified in mammals [ 11. It is of key interest to determine the unique function of each GLUT isoform in an effort to broaden our understanding of whole body glucose homeostasis. An isoform of relevance to the regulation of glucose metabolism by insulin is GLUT-4. The expression of this isoform is confined to tiss...
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Garlic (Allium sativum L., Alliaceae), Persian shallot (Allium ascalonicum L., Alliaceae ) and Sage (Salvia officinalis L., Lamiaceae) are believed to have hypoglycemic properties and have been used traditionally as antidiabetic herbal medicines in Iran. In this study, diabetes was induced by subcutaneous injection of alloxan monohydrate (100 mg kg−1) to male Wistar rats. Antidiabetic effects of...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 1994
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.126.5.1123